Developing control systems for medical applications poses particular challenges, some of which are unique to this field. Physiological systems involve a multitude of interacting subsystems and networks, with multiple feedforward and feedback loops, and interactions at many levels. The dynamics vary from one individual to another, and within the same individual over time. Many times [...]
Housed in the Chemical Engineering department at UCSB, the Doyle group is comprised of a diverse group of researchers coming from backgrounds such as computer science, biology, mechanical engineering and chemical engineering. Contact us to inquire about open positions.
Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock
P.C. St John, T. Hirota, S.A. Kay, F.J. Doyle III, “Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock,” Proceedings of the National Academy of Sciences of the United States of America, Jan 2014. [DOI]
Note: Parameter-independent bounding of the stochastic Michaelis-Menten steady-state intrinsic noise variance
L.A. Widmer, J. Stelling, F.J. Doyle III, “Note: Parameter-independent bounding of the stochastic Michaelis-Menten steady-state intrinsic noise variance,” The Journal of Chemical Physics, vol. 139, no. 16, pp. 166102, Oct 2013. [DOI]
M. Rodriguez-Fernandez, B. Grosman, T.M. Yuraszeck, B.G. Helwig, L.R. Leon, F.J. Doyle III, M. Wang, “Modeling the Intra- and Extracellular Cytokine Signaling Pathway under Heat Stroke in the Liver,” PLoS ONE, vol. 8, no. 9, pp. e73393, 2013. [DOI]