Development of new methodologies for modeling biological systems. Working on different projects aiming to understand by means of mathematical modeling diverse biological phenomena with particular focus on heat stroke.
B.S., Chemical Engineering, University of Santiago de Compostela, Spain, 2001
Ph.D., Chemical Engineering, IIM-CSIC, University of Vigo, Spain, 2007
M. Rodriguez-Fernandez, B. Grosman, T.M. Yuraszeck, B.G. Helwig, L.R. Leon, F.J. Doyle III, M. Wang, “Modeling the Intra- and Extracellular Cytokine Signaling Pathway under Heat Stroke in the Liver,” PLoS ONE, vol. 8, no. 9, pp. e73393, 2013. [DOI]
K. Sriram, M. Rodriguez-Fernandez, F.J. Doyle III, “A Detailed Modular Analysis of Heat-Shock Protein Dynamics under Acute and Chronic Stress and its Implication in Anxiety Disorders”, PLoS ONE, vol. 7, no. 8, e42958, August 2012. [DOI]
M. Rodriguez-Fernandez, J.R. Banga, F.J. Doyle III, “Novel global sensitivity analysis methodology accounting for the crucial role of the distribution of input parameters: application to systems biology models”, International Journal of Robust and Nonlinear Control, vol. 22, no. 10, pp. 1082–1102, July 2012. [DOI]
K. Sriram, M. Rodriguez-Fernandez, F.J. Doyle III, “Modeling Cortisol Dynamics in the Neuro-endocrine Axis Distinguishes Normal, Depression, and Post-traumatic Stress Disorder (PTSD) in Humans”, PLoS Computational Biology, vol. 8, no. 2, e1002379, February 2012. [DOI]
T.M Yuraszeck, P. Neveu, M. Rodriguez, A. Robinson, K.S. Kosik, F.J. Doyle III “Vulnerabilities in the Tau Network and the Role of Ultrasensitive Points in Tau Pathophysiology,” PLoS Comput Biol, vol. 6, no. 11, November 2010. [DOI]