Harvard SEAS: “Research sheds light the neural structure that controls our sleep, eating habits, hormones and more.” See within for press from our most recent study of the circadian clock.
Harvard SEAS: here
UCSB Current: here
This has been featured elsewhere, including:
ExtremeTech
The Daily Mail
While the overall effects of circadian activities have been studied, relatively little is understood about the structure of the network of brain cells as they communicate to control the synchronization process. In a paper that appears in the Proceedings of the National Academy of Sciences, UC Santa Barbara [and Harvard!] researchers and collaborators infer the architecture of the suprachiasmatic nucleus (SCN), the control center for the circadian processes in mammals.
Read more: here or here
Photo credit: Cristina Mazuski, Herzog Lab, WUSTL
See a press release covering our recent publication, Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock:
UC Santa Barbara researchers’ new insight into mammalian circadian rhythms could lead to therapies for certain metabolic disorders like obesity and diabetes – See more at: http://www.news.ucsb.edu/2014/013919/resetting-metabolic-clock#sthash.kbLzwK6r.dpuf
A press release for a recent paper published in collaboration with researchers from UCSD.
Full Citation:
T. Hirota, J. W. Lee, P. C. St. John, M. Sawa, K. Iwaisako, T. Noguchi, P. Y. Pongsawakul, T. Sonntag, D. K. Welsh, D. a Brenner, F. J. Doyle, P. G. Schultz, and S. a Kay, “Identification of Small Molecule Activators of Cryptochrome.,” Science, vol. 337, no. 6098, pp. 1094–1097, Jul. 2012.
J.H. Abel, K. Meeker, D. Granados-Fuentes, P.C. St. John, T.J. Wang, B.B. Bales, F.J. Doyle III, E.D. Herzog, L.R. Petzold. “Functional network inference of the suprachiasmatic nucleus.” Proceedings of the National Academy of Sciences of the United States of America, 113(16), 2016. doi:10.1073/pnas.1521178113
J.H. Abel, L.A. Widmer, P.C. St. John, J. Stelling, and F.J. Doyle III, ”
A Coupled Stochastic Model Explains Differences in Cry Knockout Behavior.” IEEE Life Sciences Letters, Jun 2015. doi:10.1109/LLS.2015.2439498
St John PC, Doyle FJ III.
PLoS Comput Biol. 2015 Nov 20;11(11):e1004451. doi: 10.1371/journal.pcbi.1004451.
P.C. St John, S.R. Taylor, J.H. Abel, F.J. Doyle III, “Amplitude metrics for cellular circadian bioluminescence reporters,” Biophysical Journal, vol. 107, no. 11, pp. 2712-22,Dec 2014. [DOI]
P.C. St John, T. Hirota, S.A. Kay, F.J. Doyle III, “Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock,” Proceedings of the National Academy of Sciences of the United States of America, Jan 2014. [DOI]
P.C. St John, F.J. Doyle III, “Estimating confidence intervals in predicted responses for oscillatory biological models,” BMC Systems Biology, vol. 7, no. 1, pp. 71, Jul 2013. [DOI]
T. Hirota, J.W. Lee, P.C St. John, M. Sawa, K. Iwaisako, T. Noguchi, P.Y. Pongsawakul, T. Sontag, D.K. Welsh, D.A. Brenner, F.J. Doyle III, P.G. Schultz, S.A. Kay, “Identification of small molecule activators of cryptochrome,” Science, vol. 337, no. 6098, pp. 1094-1097, July 2012. [DOI]
A.R. Murphy, P. St John, D.L. Kaplan, “Modification of silk fibroin using diazonium coupling chemistry and the effects on hMSC proliferation and differentiation,” Biomaterials, vol. 29, no. 19, pp. 2829-38,Jul 2008. [DOI]
