Developing control systems for medical applications poses significant challenges, some of which are unique to this field. Physiological systems involve a multitude of interacting subsystems and networks, with multiple feedforward and feedback loops. The dynamics vary both between different individuals, and within the same individual over time. Measurement and estimation of both inter- and intra-patient […]
Based at Harvard University, the Doyle group is comprised of a diverse group of researchers, coming from backgrounds such as computer science, biology, and chemical engineering. Contact us to inquire about open positions.
Mechanistic inferences on metabolic dysfunction in PTSD from an integrated model and multi-omic analysis: Role of glucocorticoid receptor sensitivity
Pramod R. Somvanshi, Synthia H. Mellon, Janine D. Flory, Duna Abu-amara, PTSD Systems Biology Consortium, Owen M. Wolkowitz, Rachel Yehuda, Marti Jett, Leroy Hood, Charles Marmar, and Francis J. Doyle. 2019. American Journal of Physiology: Endocrinology and Metabolism.
B. Misganaw, G. Guffanti, A. Lori, D. Abu-Amara, J. D. Flory, SBPBC, S. Mueller, R. Yehuda, M. Jett, C. R. Marmar, K. J. Ressler, & F. J. Doyle III. 2019. Translational Psychiatry 9.